Wed Jun 9 10:13:50 2021
(*5e05c158*):: Coronavirus: Latest developments [What Think Tanks are thinking]
27-05-2021
+Public!
A year and a quarter after the Covid-19 pandemic first broke out, the disease continues to wreak havoc in many countries around the world. The process of vaccination continues at varying speeds across the globe, but with a clear discrepancy between rich and poor countries. Significant pressure is being applied by NGOs, international institutions and a number of national governments to help poor countries with vaccinations, notably because of actual or potential dangerous mutations of the coronavirus. Meanwhile, the EU institutions are close to finalising a ‘digital green certificate’ to facilitate safe and free movement between Member States, by providing proof that a person has either been vaccinated against Covid-19, received a negative test result, or recovered from the disease and carries antibodies. This note offers links to recent commentaries, studies and reports from international think tanks on the coronavirus and related issues. More studies on the topics can be found in a previous edition in this series, published in February 2021.
— Coronavirus: Latest developments [What Think Tanks are thinking] – Think Tank
— A year and a quarter after the Covid-19 pandemic first broke out, the disease continues to wreak havoc in many countries around the world. The process of vaccination continues at varying speeds across the globe, but with a clear discrepancy between rich and poor countries. Significant pressure is being applied by NGOs, international institutions and a number of national governments to help poor countries with vaccinations, notably because of actual or potential dangerous mutations of the coronavirus. Meanwhile, the EU institutions are close to finalising a ‘digital green certificate’ to facilitate safe and free movement between Member States, by providing proof that a person has either been vaccinated against Covid-19, received a negative test result, or recovered from the disease and carries antibodies. This note offers links to recent commentaries, studies and reports from international think tanks on the coronavirus and related issues. More studies on the topics can be found in a previous edition in this series, published in February 2021.
(*5e05c158*):: Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues.
(*5e05c158*):: Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues.
(*5e05c158*):: An unresolved issue of SARS-CoV-2 disease is that patients often remain positive for viral RNA as detected by PCR many weeks after the initial infection in the absence of evidence for viral replication. We show here that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of the infected cell and be expressed as chimeric transcripts fusing viral with cellular sequences. Importantly, such chimeric transcripts are detected in patient-derived tissues. Our data suggest that, in some patient tissues, the majority of all viral transcripts are derived from integrated sequences. Our data provide an insight into the consequence of SARS-CoV-2 infections that may help to explain why patients can continue to produce viral RNA after recovery.